Calculate the approximate starting dose of Methadone hydrochloride tablets to be given every 12 hours. Round down, if necessary, to the appropriate Methadone hydrochloride tablets strengths available. Take rasagiline by mouth with or without food. Abuse and addiction are separate and distinct from physical dependence and tolerance. Health care providers should be aware that addiction may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. In addition, abuse of opioids can occur in the absence of true addiction.
The activity of oxycodone hydrochloride is primarily due to the parent drug oxycodone. Read the Guide provided by your before you start using and each time you get a refill because new information may be available. If you have any questions regarding the information, consult your doctor or pharmacist. Never give anyone else your Oxycodone Hydrochloride Capsules. They could die from taking it. Store Oxycodone Hydrochloride Capsules away from children and in a safe place to prevent stealing or abuse. Selling or giving away Oxycodone Hydrochloride Capsules is against the law. Each tablet for oral administration contains 5 mg, 10 mg, 15 mg, 20 mg or 30 mg, of Oxycodone hydrochloride, USP.
Do not suddenly stop taking rasagiline without checking with your doctor. You may experience side effects such as fever or confusion. Abuse and addiction are separate and distinct from physical dependence and tolerance. Healthcare providers should be aware that addiction may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. In addition, abuse of opioids can occur in the absence of true addiction. Take mirtazapine in the evening before bedtime unless your doctor tells you otherwise. It is very important to take prasugrel exactly as directed. not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Also, do not stop using this medication unless directed by your doctor.
Importance of not breaking orally disintegrating tablets. Tell patients that this drug may take 1 to 4 weeks until clinical improvement is observed; patients should be warned to avoid abrupt discontinuation of this drug. However, based on postmarketing reports, there is a possibility of more serious outcomes including fatalities at dosages much higher than the therapeutic dose, especially with mixed overdoses. In these cases, QT prolongation and Torsades de Pointes have also been reported see and sections. Dosage Adjustment During Pregnancy: The disposition of oral Methadone has been studied in approximately 30 pregnant patients in second and third trimesters. Total body clearance of Methadone was increased in pregnant patients compared to the same patients postpartum or to non-pregnant opioid-dependent women. The terminal half-life of Methadone is decreased during second and third trimesters. The decrease in plasma half-life and increased clearance of Methadone resulting in lower Methadone trough levels during pregnancy can lead to withdrawal symptoms in some pregnant patients.
HDD reduced fetal blood testosterone and androstenedione in males. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Oxycodone Hydrochloride Capsules and any potential adverse effects on the breastfed infant from Oxycodone Hydrochloride Capsules or from the underlying maternal condition. Advise the patient to read the FDA-approved patient labeling Medication Guide and Instruction for Use. See Specific Drugs under Interactions. Do not change your dose. Take Methadone hydrochloride tablets exactly as prescribed by your healthcare provider. Use the lowest dose possible for the shortest time needed. Frequent: myasthenia, arthralgia; infrequent: arthritis, tenosynovitis; rare: pathologic fracture, osteoporosis fracture, bone pain, myositis, tendon rupture, arthrosis, bursitis. Taking Oxycodone Hydrochloride Capsules with other opioid medicines, benzodiazepines, alcohol, or other central nervous system depressants including street drugs can cause severe drowsiness, decreased awareness, breathing problems, coma, and death. If you take REMERONSolTab, you should not take any other medicines that contain mirtazapine including REMERON Tablets. Z” debossed on one side. Tramadol hydrochloride tablets contain tramadol, an opioid agonist and inhibitor of norepinephrine and serotonin reuptake. Although the mode of action is not completely understood, the analgesic effect of tramadol is believed to be due to both binding to μ-opioid receptors and weak inhibition of re-uptake of norepinephrine and serotonin.
Toxic epidermal necrolysis, Urticaria, Vesicles. Mirtazapine is a moderate peripheral α1 adrenergic antagonist, a property that may explain the occasional reported in association with its use. Get emergency help right away if you take too much Oxycodone Hydrochloride Capsules overdose. When you first start taking Oxycodone Hydrochloride Capsules, when your dose is changed, or if you take too much overdose serious or life-threatening breathing problems that can lead to death may occur. Think of a way to change the nightmare. Krakow declines to tell his patients what sort of change to make, encouraging them to rely on their intuition to make an appropriate change. Patients should be advised to inform their physician if they are taking, or intend to take, any prescription or over-the-counter drugs, since there is a potential for Mirtazapine Tablets to interact with other drugs. Hepatic impairment: Use with caution in patients with hepatic impairment. Clinically significant transaminase elevations have been observed. An opioid pain medicine that can put you at risk for overdose and death. Even if you take your dose correctly as prescribed you are at risk for opioid addiction, abuse, and misuse that can lead to death. Acute overdosage with tramadol hydrochloride tablets can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, in some cases, pulmonary edema, bradycardia, hypotension, partial or complete airway obstruction, atypical snoring, seizures, and death. Marked mydriasis rather than miosis may be seen with hypoxia in overdose situations. Methotrimeprazine: CNS Depressants may enhance the CNS depressant effect of Methotrimeprazine. Methotrimeprazine may enhance the CNS depressant effect of CNS Depressants. Management: Reduce adult dose of CNS depressant agents by 50% with initiation of concomitant methotrimeprazine therapy. Further CNS depressant dosage adjustments should be initiated only after clinically effective methotrimeprazine dose is established. Dabrafenib: May decrease the serum concentration of CYP3A4 Substrates. Management: Seek alternatives to the CYP3A4 substrate when possible. If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely particularly therapeutic effects. For a given dose, the same total amount of Morphine Sulfate is available from Morphine Sulfate Tablets, and extended-release morphine formulations. The extended duration of release of Morphine Sulfate from extended-release formulations results in reduced maximum and increased minimum plasma Morphine Sulfate concentrations than with shorter acting Morphine Sulfate products. Conversion from Morphine Sulfate Tablets to the same total daily dose of an extended-release formulation could lead to excessive sedation at peak serum levels. Therefore, conversion to extended-release morphine formulations must be accompanied by close observation for signs of excessive sedation and respiratory depression. Tablets: white to off-white, modified rectangle shaped convex tablets and are debossed with a score between “57” and “71” on one side and on the other side. Plasma levels are linearly related to dose over a dose range of 15 to 80 mg. The mean elimination half-life of mirtazapine after oral administration ranges from approximately 20 to 40 hours across age and gender subgroups, with females of all ages exhibiting significantly longer elimination half-lives than males mean half-life of 37 hours for females vs. 26 hours for males. MAO inhibitors and other substances. DSM-III criteria for major depressive disorder. prednisone
If a CYP2D6 inhibitor is discontinued, consider lowering tramadol hydrochloride tablets dosage until stable drug effects are achieved. Follow patients closely for adverse events including respiratory depression and sedation. Renal Impairment: Morphine pharmacokinetics are altered in patients with renal failure. The AUC is increased and clearance is decreased and the metabolites, M3G and M6G, may accumulate to much higher plasma levels in patients with renal failure as compared to patients with normal renal function. Adequate studies of the pharmacokinetics of morphine in patients with severe renal impairment have not been conducted. To evaluate the effect of tramadol, a CYP2D6 substrate on quinidine, an in vitro drug interaction study in human liver microsomes was conducted. The results from this study indicate that tramadol has no effect on quinidine metabolism , PRECAUTIONS; Drug Interactions. Ensure accuracy when prescribing, dispensing, and administering morphine sulfate oral solution to avoid dosing errors due to confusion between mg and mL, and with other morphine solutions of different concentrations, which could result in accidental overdose and death. Ensure the proper dose is communicated and dispensed. When writing prescriptions, include both the total dose in mg and the total dose in volume. During an emergency period of no longer than 3 days while definitive care for the addiction is being sought in an appropriately licensed facility pursuant to 21 CFR 1306. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking rasagiline while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you take rasagiline, check with your doctor. Discuss any possible risks to your baby. Exhibits potent antagonism of histamine H 1 receptors. Take your prescribed dose as indicated by your health care provider. The maximum dosage is 1 or 2 tablets every 4 to 6 hours, as needed for pain relief. Do not take more than your prescribed dose and do not take more than 8 tablets per day. If you miss a dose, take your next dose at your usual time. Greater risks for developing a discontinuation syndrome have been associated with antidepressants with shorter half-lives, longer durations of treatment, and abrupt discontinuation. For antidepressants of short or intermediate half-lives, symptoms may emerge within 2 to 5 days after treatment discontinuation and last 7 to 14 days APA 2010; Fava 2006; Haddad 2001; Shelton 2001; Warner 2006. When a patient who has been taking tramadol hydrochloride tablets regularly and may be physically dependent no longer requires therapy with tramadol hydrochloride tablets, taper the dose gradually, by 25% to 50% every 2 to 4 days, while monitoring carefully for signs and symptoms of withdrawal. If the patient develops these signs or symptoms, raise the dose to the previous level and taper more slowly, either by increasing the interval between decreases, decreasing the amount of change in dose, or both. Do not abruptly discontinue tramadol hydrochloride tablets in a physically-dependent patient. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. What are the ingredients in REMERONSolTab? How should I take REMERONSolTab? ehet.info oxcarbazepine
There is a relationship between increasing tramadol plasma concentration and increasing frequency of dose-related opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory depression. White K, Simpson G. The combined use of MAOIs and tricyclics. Metabolized by CYP2D6, CYP3A4, and CYP1A2; a b not a potent inhibitor of CYP2D6, CYP3A4, and CYP1A2. If a CYP3A4 inhibitor is discontinued, consider increasing the Oxycodone HCl dosage until stable drug effects are achieved. Monitor for signs of opioid withdrawal. Monitor patients for signs of urinary retention or reduced gastric motility when tramadol hydrochloride tablets are used concomitantly with anticholinergic drugs. Oxycodone needed, 3 the degree of opioid tolerance, 4 the general condition and medical status of the patient, and 5 the balance between pain control and adverse experiences. Fusidic Acid Systemic: May increase the serum concentration of CYP3A4 Substrates. Studies demonstrated that Methadone treatment of male rats for 21 to 32 days prior to mating with Methadone-naïve females did not produce any adverse effects, suggesting that prolonged Methadone treatment of the male rat resulted in tolerance to the developmental toxicities noted in the progeny. Mechanistic studies in this rat model suggest that the developmental effects of “paternal” Methadone on the progeny appear to be due to decreased testosterone production. These animal data mirror the reported clinical findings of decreased testosterone levels in human males on Methadone maintenance therapy for opioid addiction and in males receiving chronic intraspinal opioids. Taking Oxycodone HCl tablets with certain other medicines can cause serious side effects that could lead to death. Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing tramadol hydrochloride tablets. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity and advising the patient on the proper disposal of unused drug ; . Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product. Methadone hydrochloride tablets contain Methadone, a Schedule II controlled substance. Drink alcohol or use prescription or over-the-counter medicines that contain alcohol. Using products containing alcohol during treatment with Morphine Sulfate Tablets may cause you to overdose and die. Methadone hydrochloride tablets, and monitor all patients receiving Methadone hydrochloride tablets for the development of these behaviors and conditions. MetyroSINE: CNS Depressants may enhance the sedative effect of MetyroSINE. Buprenorphine: CNS Depressants may enhance the CNS depressant effect of Buprenorphine. D-glucuronic acid to produce glucuronides or with sulfuric acid to produce morphine-3-etheral sulfate. While a small fraction less than 5% of morphine sulfate is demethylated, virtually all morphine sulfate is converted by hepatic metabolism to the 3- and 6-glucuronide metabolites M3G and M6G; about 50% and 15%, respectively. M6G has been shown to have analgesic activity but crosses the blood-brain barrier poorly, while M3G has no significant analgesic activity.
Morphine sulfate oral solution is for oral use only. Abuse of morphine sulfate oral solution poses a risk of overdose and death. The risk is increased with concurrent abuse of morphine sulfate oral solution with alcohol and other central nervous system depressants. Parenteral drug abuse is commonly associated with transmission of infectious diseases such as hepatitis and HIV. Potential pharmacokinetic interaction decreased mirtazapine metabolism with inhibitors of CYP2D6, CYP3A4, or CYP1A2. Physical dependence results in withdrawal symptoms after abrupt discontinuation or a significant dosage reduction of a drug. Monitor for possible worsening of depression or suicidality, especially at the beginning of therapy or during periods of dosage adjustments. 19 b See Worsening of Depression and Suicidality Risk under Cautions. Monitor patients for signs of urinary retention or reduced gastric motility when morphine sulfate oral solution is used concomitantly with anticholinergic drugs. Oxycodone HCl is contraindicated in patients with gastrointestinal obstruction, including paralytic ileus. Assess each patient's risk for opioid addiction, abuse, or misuse prior to prescribing tramadol hydrochloride tablets, and monitor all patients receiving tramadol hydrochloride tablets for the development of these behaviors and conditions. Desipramine: Blood levels of desipramine have increased with concurrent Methadone administration. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions. cheapest dapsone order now usa
Nervous: agitation, anxiety, confusion, dry mouth, hypertonia, hypesthesia, nervousness, neuralgia, personality disorder, tremor, and vasodilation. Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed Oxycodone Hydrochloride Capsules. Addiction can occur at recommended dosages and if the drug is misused or abused. In case of overdose, priorities are the re-establishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures including oxygen and vasopressors in the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced life-support techniques. The opioid antagonists, naloxone or nalmefene, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory depression secondary to tramadol overdose, administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to tramadol overdose. The safety and efficacy of tramadol hydrochloride tablets in patients under 16 years of age have not been established. The use of tramadol hydrochloride tablets in the pediatric population is not recommended. While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of morphine sulfate oral solution, the risk is greatest during the initiation of therapy or following a dosage increase. Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy with and following dosage increases of morphine sulfate oral solution. The Oxycodone in Oxycodone HCl may increase the frequency of seizures in patients with seizure disorders, and may increase the risk of seizures occurring in other clinical settings associated with seizures. Monitor patients with a history of seizure disorders for worsened seizure control during Oxycodone HCl therapy. Hepatic impairment may reduce clearance. rizatriptan online reviews forum
Mirtazapine tablets may cause serious side effects: 1. See "What is the most important information I should know about mirtazapine tablets? These studies revealed no evidence of teratogenicity or embryo-fetal toxicity due to Oxycodone. This medication works best when the amount of medicine in your body is kept at a constant level. Therefore, take this medication at evenly spaced intervals throughout the day and night. Oxycodone HCl tablets, USP 20 mg are supplied as gray, round, biconvex tablets debossed with “A” on the left and “50” on the right of the score on one side and plain on the other side. Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations. Selegiline is an enzyme blocker MAO inhibitor that works by slowing the breakdown of certain natural substances in the neurotransmitters such as dopamine, norepinephrine, and serotonin. Sustained therapy may be required; monitor periodically for need for continued therapy. Methadone to 10 mg oral Methadone. Read the Guide available from your before you start using and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Saturation of plasma protein binding occurs only at concentrations outside the clinically relevant range. Mirtazapine did not significantly affect the pharmacokinetics of phenytoin. What Is Mirtazapine and How Does It Work? The safety and effectiveness and the pharmacokinetics of Morphine Sulfate Tablets in pediatric patients below the age of 18 have not been established. Based on two studies in 22 breastfeeding women maintained on Methadone treatment, Methadone was present in low levels in human milk, and did not show adverse reactions in breastfed infants. Serotonin Syndrome: Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of opioids with serotonergic drugs.
Importance of informing patients with phenylketonuria that orally disintegrating tablets contain aspartame. Harris says. "But with help, they get good at priming the pump for imagery. Pamelor nortriptyline hydrochloride US prescribing information. Lehigh Valley Technologies, Inc. Instruct patients how to properly take tramadol hydrochloride tablets. In an individual physically dependent on opioids, administration of the recommended usual dosage of the antagonist will precipitate an acute withdrawal syndrome. The severity of the withdrawal symptoms experienced will depend on the degree of physical dependence and the dose of the antagonist administered. If a decision is made to treat serious respiratory depression in the physically dependent patient, administration of the antagonist should be initiated with care and by titration with smaller than usual doses of the antagonist. buy flonase from trusted pharmacy
The safety and effectiveness and the pharmacokinetics of morphine sulfate oral solution in pediatric patients below the age of 18 have not been established. St John's Wort: May decrease the serum concentration of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Administration of Methadone with other CYP3A4 inducers may result in withdrawal symptoms. The use of Methadone in patients already known to have a prolonged QT interval has not been systematically studied. An electronic copy of this medication guide can be obtained from www. Some medical conditions may interact with mirtazapine. Management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Mirtazapine should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. They may also have an increased risk of suicidal thoughts or actions. Morphine produces respiratory depression by direct action on brain stem respiratory centers. The respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to both increases in carbon dioxide tension and electrical stimulation. Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy and there is no evidence of risk in later trimesters. While naloxone will reverse some, but not all, symptoms caused by overdosage with tramadol, the risk of seizures is also increased with naloxone administration. In animals, convulsions following the administration of toxic doses of tramadol hydrochloride tablets could be suppressed with barbiturates or benzodiazepines but were increased with naloxone. Naloxone administration did not change the lethality of an overdose in mice. Hemodialysis is not expected to be helpful in an overdose because it removes less than 7% of the administered dose in a 4-hour dialysis period. seroflo achat canada
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use REMERONSolTab for a condition for which it was not prescribed. Do not give REMERONSolTab to other people, even if they have the same condition. It may harm them. The oxycodone in Oxycodone Hydrochloride Capsules may cause spasm of the sphincter of Oddi. Opioids may cause increases in serum amylase. Monitor patients with biliary tract disease, including acute pancreatitis, for worsening symptoms. The use of Oxycodone HCl is not recommended for patients taking MAOIs or within 14 days of stopping such treatment. Mirtazapine Tablets have not been systematically evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or other significant heart disease. Mirtazapine Tablets were associated with significant orthostatic hypotension in early clinical pharmacology trials with normal volunteers. Orthostatic hypotension was infrequently observed in clinical trials with depressed patients. Mirtazapine Tablets should be used with caution in patients with known cardiovascular or cerebrovascular disease that could be exacerbated by hypotension history of myocardial infarction, angina, or ischemic stroke and conditions that would predispose patients to hypotension dehydration, hypovolemia, and treatment with antihypertensive medication. Adverse events reported since market introduction, which were temporally but not necessarily causally related to mirtazapine therapy, include cases of the ventricular arrhythmia Torsades de Pointes. In the majority of these cases, however, concomitant drugs were implicated. Oxycodone is metabolized in part to oxymorphone via the cytochrome P450 isoenzyme CYP2D6. Claghorn JL, Lesem MD. A double-blind placebo-controlled study of Org 3770 in depressed outpatients. J Affect Disord. Rasagiline may cause high blood pressure. Have your blood pressure checked while taking rasagiline. Discuss any questions or concerns with your doctor. At least 14 days should elapse between discontinuation of an MAOI intended to treat psychiatric disorders and initiation of therapy with Mirtazapine Tablets. CYP1A2 Inhibitors Strong: May decrease the metabolism of CYP1A2 Substrates. The electrocardiograms for 338 patients who received Mirtazapine Tablets and 261 patients who received placebo in 6-week, placebo-controlled trials were analyzed.
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In studies including geriatric patients, treatment-limiting adverse events were higher in subjects over 75 years of age compared to those under 65 years of age. Specifically, 30% of those over 75 years of age had gastrointestinal treatment-limiting adverse events compared to 17% of those under 65 years of age. Rasagiline is a monoamine oxidase inhibitor MAOI. Exactly how it works is not known. It may help to increase a substance in the brain that affects motor function. When these combinations are prescribed by your doctor, you will require closer monitoring to minimize your risk of bleeding. Keep all medical and laboratory appointments. maxalt
Dispense in a tight, light-resistant container as defined in USP with a child-resistant closure. Mirtazapine is a moderate peripheral α 1-adrenergic antagonist, a property that may explain the occasional orthostatic hypotension reported in association with its use. Drink alcohol or use prescription or over-the-counter medicines that contain alcohol. Using products containing alcohol during treatment with tramadol hydrochloride tablets may cause you to overdose and die. C. 2. Keep Mirtazapine Tablets away from light. 3. Keep Mirtazapine Tablets bottle closed tightly.
Methadone undergoes hepatic N-demethylation by several cytochrome P450 CYP isoforms, including CYP3A4, CYP2B6, CYP2C19, CYP2C9, and CYP2D6. The concomitant use of Methadone hydrochloride tablets and CYP3A4, CYP2B6, CYP2C19, CYP2C9, or CYP2D6 inhibitors can increase the plasma concentration of Methadone, resulting in increased or prolonged opioid effects, and may result in a fatal overdose, particularly when an inhibitor is added after a stable dose of Methadone hydrochloride tablets is achieved. Human Data: Reported studies have generally compared the benefit of Methadone to the risk of untreated addiction to illicit drugs; the relevance of these findings to pain patients prescribed Methadone during pregnancy is unclear. Pregnant women involved in Methadone maintenance programs have been reported to have significantly improved prenatal care leading to significantly reduced incidence of obstetric and fetal complications and neonatal morbidity and mortality when compared to women using illicit drugs. Several factors, including maternal use of illicit drugs, nutrition, infection and psychosocial circumstances, complicate the interpretation of investigations of the children of women who take Methadone during pregnancy. Information is limited regarding dose and duration of Methadone use during pregnancy, and most maternal exposure appears to occur after the first trimester of pregnancy.
A” on the left and “51” on the right of the score on one side and plain on the other side. Fractures: Bone fractures have been associated with antidepressant treatment. Consider the possibility of a fragility fracture if an antidepressant-treated patient presents with unexplained bone pain, point tenderness, swelling, or bruising Rabenda 2013; Rizzoli 2012. No suicides occurred in any of the pediatric trials. There were suicides in the adult trials, but the number was not sufficient to reach any conclusion about drug effect on suicide. Morphine is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of morphine is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with morphine. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression.